list of recent publications

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Original papers

*New Cdc25B tyrosine phosphatase inhibitors, Nocardiones A and B, produced by Nocardia* sp. TP-A0248: Toxonomy, fermentation, isolation, structural elucidation and biological properties**		J. Antibiotics, 53: 337-344, 2000
	T. Otani, Y. Sugimoto, Y. Aoyagi, Y. Igarashi, T. Furumai, N. Saito, Y. Yamada, T. Asao, and T. Oki
Xanthoepocin, a new antibiotic from Penicillium simplicissimum IFO5762		J. Antibiotics, 53: 928-933, 2000
	Y. Igarashi, Y. Kuwamori, K. Takagi, T. Ando, R. Fudou, T. Furumai, and T. Oki
Interaction of three pradimicin derivatives with divalent cations in aqueous solution		Spectrochimica Acta, Pat A, 56: 1233-1243, 2000
	M. Hu, Y. Ishizuka, Y. Igarashi, T. Oki, and H. Nakanishi
*Novel triene-beta-lactone antibiotics, oxazolomycin derivatives and its isomer, produced by Streptomyces* sp. KSM-2690**		J. Antibiotics, 53: 1397-1400, 2000
	T. Otani, K. Yoshida, H. Kubota, S. Kawai, S. Ito, H. Hori, T. Ishiyama and T. Oki
*Materials for the fungus flora of Japan (56) Mariannaea* camptospora and M. elegans var. punicea from Japan**		Mycoscience 41: 411-414, 2000
	Toru Okuda and Kozo Yamamoto* *Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory
*Production of TMC-151, TMC-154 and TMC-171, a new class of antibiotics, is specific to ‘Gliocladium* roseum’ group**		Mycoscience 41: 239-253, 2000
	Toru Okuda, Jun Kohno, Noboru Kishi, Yasuyuki Asai, Maki Nishio, and Saburo Komatsubara* *Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory
*Selective isolation and distribution of Actinobispora* strains in soil**		Can. J. Microbiol. 46: 708-715, 2000
	Shin-ichi Suzuki, Toru Okuda, and Saburo Komatsubara *Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory
*Selective isolation and distribution of Actinomadura* rugatobispora strains in soil**		Actinomycetol. 14: 27-33, 2000
	Shin-ichi Suzuki, Kozo Yamamoto, Toru Okuda, Maki Nishio, Noryuki Nakanishi, and Saburo Komatsubara* *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
Screening of bioactive compounds from actinomycetes isolated in Toyama Prefecture		Toyama Prefectural University Kiyo 11: 47-54, 2001
	Yasuhiro Igarashi, Yuko Kuwamori, Tamotsu Furumai, and Toishikazu Oki Toyama Prefectural University, Biotechnology Research Center
*Selective isolation and distribution of the genus Planomonospora* in soils**		Can. J. Microbiol. 47: 253-263, 2001
	Shin-ichi Suzuki, Toru Okuda, and Saburo Komatsubara *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
Aurantiamide acetate, a selective cathepsin inhibitor, produced by Aspergillus peincilloides		Biosci. Biotechnol. Biochem. 65: 1195-1197, 2001
	Kengo Isshiki, Yasuyuki Asai, Sumiko Tanaka, Maki Nishio, Toru Okuda, Saburo Komatsubara, Naoki Sakurai *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
*Selective isolation and study on the global distribution of the genus Planobispora* in soils**		Can. J. Microbiol. 47: 979-986, 2001
	Shin-ichi Suzuki, Toru Okuda, and Saburo Komatsubara *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
*TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium* sp. TC1068 Taxonomy, fermentation and biological activity**		J. Antibiot. 54: 421-427, 2001
	Naomitsu Hirano, Jun Kohno, Shiho Tsunoda, Maki Nishio, Noboru Kishi, Toru Okuda, Kimio Kawano, Saburo Komatsubara* and Noriyuki Nakanishi* *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
Roridin L, M and verrucarin M, new macrocycilc trichothecene group antitumor antibiotics, from Myrothecium verrucaria		J. Antibiot. 54: 980-983, 2001
	Yasunobu Murakami, Toru Okuda and Kazutoshi Shindo *Pharmaceuticl Research Laboratory, Kirin Brewery Co., Ltd.
*Japanese fungicolous ascomycetes, three Hypomyces* species**		Trans. mycol. Soc. Japan 42: 199-209, 2001
	Toshiyuki Tokiwa* and Toru Okuda *N.M.G. Co., Ltd.
An effective tool for homogeneous assays using a simple robot arm with stackers - TRISTAN
	Kazuyoshi Yajima, Takanori Ohgaru, Yoshifumi Hashimoto, Naoki Suto and Toru Okuda *Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.	J. Biomol. Screening 7: 89-94, 2002
Biosynthesis of hibarimicins I. 13C-labelled experiments
	Hiroshi Hori, Takayuki Kajiura, Yasuhiro Igarashi, Tamotsu Furumai, Kazuaki Higashi, Tadayuki Ishiyama, Masakazu Uramoto, Yoshimasa Uehara and Toshikazu OKi	J. Antibiot. 55: 46-52, 2002
Biosynthesis of hibarimicins III. Structures of new hibarimicin-related metabolites produced by blocked mutants		J. Antibiot. 55: 61-70, 2002
	Yasuhiro Igarashi, Takayuki Kajiura, Tamotsu Furumai, Hiroshi Hori, Kazuaki Higashi, Tadayuki Ishiyama, Masakazu Uramoto, Yoshimasa Uehara and Toshikazu Oki
*Kosinostatin, a quinocycline antibiotic with antitumor activity from Micromonospora* sp. TP-A0468**		J. Antibiot. 55: 128-133, 2002
	Tamotsu Furumai, Yasuhiro Igarashi, Hiroko Higuchi, Noriko SAito and Toshikazu Oki
*NMR analysis of quinocycline antibiotics: structure determination of kosinostatin, an antitumor substance from Micromonospora* sp. TP-A0468**		J. Antibiot. 55: 134-140, 2002
	Yasuhiro Igarashi, Hiroko Higuchi, Toshikazu Oki and Tamotsu Furumai
*Effect of hibarimicins and hibarimicin-related compounds produced by Microbispora* on v-Src kinase activity and growth and differentiation of human myeloid leukemia HL-60 cells**		J. Antibiot. 55: 270-278, 2002
	Sung Ig Cho, Kidesuke Fukazawa, Yoshio Honma, Takayuki Kajiura, Hiroshi Hori, Yasuhiro Igarashi, Tamotsu Furumai, Toshikazu Oki and Yoshimasa Uehara
Paecilopeptin, a new cathepsin S inhibitor produced by Paecilomyces carneus		Biosci. Biotechnol. Biochem. 66: 2444-2448, 2002
	Kazutoshi Shindo, Hidefumi Suzuki, and Toru Okuda
*Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium* aurantiogriseum Dierckx TP-F0213**		J. Antibiot. 55: 371-376, 2002
	Yasuhiro Igarashi, Akira Sekine, Hidesuke Fukazawa, Yoshimasa Uehara, Kentaro Yamaguchi, Yasuyuki Endo, Toru Okuda, Tamotsu Furumai and Toshikazu Oki
*TMC-264, a novel antiallergic heptaketide produced by the fungus Phoma* sp. TC 1674**		Organic Letters 5: 1083-1085, 2003
	Masaaki Sakurai, Maki Nishio, Kouzou Yamamoto, Toru Okuda, Kimio Kawano, and Tetsuo Ohnuki
*TMC-264, a novel inhibitor of STATS6 activation produced by Phoma* sp. TC 1674**		J. Antibiot. 56: 513-519, 2003
	Masaaki Sakurai, Maki Nishio, Kouzou Yamamoto, Toru Okuda, Kimio Kawano, and Tetsuo Ohnuki
*TMC-260, a new inhibitor of IL-4 signal transduction produced by Acremonium* kiliense Gruetz TC 1703**		J. Antibiot. 56: 787-791, 2003
	Masaaki Sakurai, Hiroyuki Hoshino, Jun Kohno, Maki Nishio, Noboru Kishi, Toru Okuda, Kimio Kawano, and Tetsuo Ohnuki

Books

Media and incubation effects on morphological characteristics of Penicillium and Aspergillus		In: Integration of Modern Taxonomic Methods for Penicillium and Aspergillus Classification. Ed. by Rob A. Samson and John I. Pitt. Harwood Academic Publishers, Australia, 2000. pp83-99.
	Toru Okuda, Maren A. Klich, Keith A .Seifert, and Katsuhiko Ando** USDA Southern Regional Research Center, New Orleans, USA; Cereal and Oilseed Research Centre, Agriculture and Agri-food Canada, Research Branch, Ottawa, Canada; **Kyowa Hakko Kogyo Co., Tokyo, Japan
Biological resource centre underpinning the future of biosciences and biotechnology		Organization for Economic Cooperation and Development, OECD 2001
	OECD Taskforce Member
Biological resource centre underpinning the future of biosciences and biotechnology		Japan Bioindustry Association 2002
	Seizo Sumida, Toru Okuda, Katsuhiko Ando, Junko Watanabe, Sachiko Tamate & Fujio Ishikawa (translated)
Bioindustry as users of biological resources - based on the questionnares		In. Access to biological materials - Bioindustry and Asia Mikihiko Watanabe & Satoshi Nimura (ed.) Toyo Keizai Shinposha 2002 pp54-64
	Toru Okuda

Oral presentations

Is the natural product screening activity declining?		Asian Mycological Congress 2000, Hong Kong SAR, China. 9-13 July 2000. Invited Presentation. Abstracts 32p.
	Toru Okuda	.
Current status of natural product screening programs in Japan		Ninth International Congress for Culture Collections, Brisbane, Australia. 23-38 July, 2000. Programme and Abstracts 61p.
	Toru Okuda
Current status of natural product screening activities in Japan with emphasis on our experience		2nd Asia-Pacific Biotechnology Congress, 30th Annual Meeting of Philippine Society for Microbiology, Cebu, The Philippines. 15-19 May, 2001
	Toru Okuda, K. Yajima^, K. Yamamoto^, K. Watanabe^*, and Kiyoko Ueki^Fujisawa Pharmaceutical Co., Advanced Technology Platform Research Laboratory, ^Tanabe Seiyaku Co. Ltd., Discovery Research Laboratory, ^*Tamagawa University, Faculty of Agriculture
*Japanese species of Hypomyces and their anamorphs I (in Japanese)*		45th Annual Meeting of the Mycological Society of Japan, Tokyo. 19-20 May, 2001. Abstract of Papers C-05 55p.
	Toshiyuki Tokiwa* and Toru Okuda *N.M.G. Co.
*Fungi in Hachijo Island 1, Idriella sp., Exserticlava vasiformis, and Brachiosphaera tropicalis (in Japanese)*		45th Annual Meeting of the Mycological Society of Japan, Tokyo. 19-20 May, 2001. Abstract of Papers A-20 30p
	Toru Okuda, Kozo Yamamoto, and Noboru Kishi *Tanabe Seiyaku Co., Discovery Research Laboratory
*Use of electrolyzed water for fungal isolation (in Japanese)*		45th Annual Meeting of the Mycological Society of Japan, Tokyo. 19-20 May, 2001. Abstract of Papers B-29 5１p
	Toru Okuda, Kiyoko Ueki, Kyoko Watanabe, and Masayuki Kurihara *Tamagawa University, Faculty of Agriculture
*Mycoflora of honeybee combs (in Japanese)*		45th Annual Meeting of the Mycological Society of Japan, Tokyo. 19-20 May, 2001. Abstract of Papers B-30 5１p
	Kyoko Watanabe, Toru Okuda, and Takashi Mikawa* Tamagawa University, Faculty of Agriculture, *Mitsubishi Chemical Corp., Yokohama Research Center
The Convention on Biological Diversity and culture collections *(in Japanese)*		50th Annual Meeting of Japan Society for Culture Collections, Tokyo. 14-15 June, 2001. Symposium Abstract of Papers
	Toru Okuda
Quinone-containing actinomycetous metabolities: Lead discovery and optimizaion for medical use *(in Japanese)*		The 2001 Annual Meeting of the society for Actinomycetes Japan, MO Hall, Convention Center of Osaka University. 7-8 June, 2001. SAJ Merit Award, Awardee's Lecture
	Toshikazu Oki
Fungi are mold, not bacteria		Special lecture at Kanto Gakuin University
	Toru Okuda
Isolation of fungi consists of source + treatment + technique
	Toru Okuda
Current status of natural product screening activities in South-east Asian countries and expectation of national BRC based on the discussion in OECD
	Toru Okuda
Know-how of fermentation and sample preparation for natural product drug discovery
	Toru Okuda

Articles

Asia is hot! - report on the session on natural product screening in Asian Mycological Congress (AMC2000) (in Japanese)		Bioscience and Industry 58: 671-672, 2000
	Toru Okuda
Image of new-age biological resource centers was stressed - report on 9th International Congress for Culture Collections (in Japanese)		Bioscience and Industry 58: 815-817, 2000
	Toru Okuda and Seizo Sumida*　　*Japan Bioindustry Association
Final stage of the report of biological resource centers in OECD - development of discussions during the past two years (in Japanese)		Bioscience and Industry 59: 204-206, 2000
	Toru Okuda and Seizo Sumida*　　*Japan Bioindustry Association
Asian Mycological Congress (AMC2000) (in Japanese)		Trans. Mycol. Soc. Japan 41: 159-160, 2000
	Akira Suzuki* and Toru Okuda *Chiba University
Exploring fungal resources - chasing a dream (in Japanese)		ZENJIN No.641: 40-41, 2001
	Toru Okuda
Convention on Biological Diversity and culture collections (in Japanese)		Microbial. Cult. Coll. 17: 77-79, 2001
	Toru Okuda
Book review Methods of taxonomy and identification of microorganisms Ken'ichiro Suzuki, Akira Hiraishi & Akira Yokota Springer Verlag, Tokyo *(in Japanese)*		Biosciences and Biodindustry 60: 158, 2002
	Toru Okuda
Coffee hour: Fungi are mold, not bacteria (in Japanese)		Kosoken-dayori 50: 18-19
	Toru Okuda
Trends in natural product-based drug discovery, and roles of biotech ventures and

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Toru Okuda, K. Yajima*, K. Yamamoto**, K. Watanabe***, and Kiyoko Ueki *Fujisawa Pharmaceutical Co., Advanced Technology Platform Research Laboratory, **Tanabe Seiyaku Co. Ltd., Discovery Research Laboratory, ***Tamagawa University, Faculty of Agriculture

Toru Okuda, K. Yajima^, K. Yamamoto^, K. Watanabe^, and Kiyoko Ueki^Fujisawa Pharmaceutical Co., Advanced Technology Platform Research Laboratory, ^Tanabe Seiyaku Co. Ltd., Discovery Research Laboratory, ^Tamagawa University, Faculty of Agriculture