paper 3

Interaction of three pradimicin derivatives with divalent cations in aqueous solution

*Mei Hu, Yasuko ishizuka, **Yasuhiro Igarashi, Toshikazu Oki and Hiroshi Nakanishi *National Institute of Bioscience and Human-Technology, **Biotechnology Research Center, Toyama Prefectural University,

Spectrochimica Acta, Pat A, 56, 1233-1243, 2000.

This study focused on further analysis of the aggregation behavior of pradimicin derivatives and their interaction with cations in aqueous solution. The surface tension measurement showed a clear critical micelle concentration at 1-2 mM of the BMY aqueous solution. The role of Zn²⁺ in replacing the Ca²⁺ was examined using ¹H-NMR method. From changes in the NMR spectrum and precipitability, it was concluded that zinc ion has lower affinity and higher precipitating ability to BMY than the divalent cations of alkaline earth metal. The supramolecular behavior of T2 is similar to BMY whether or not Ca²⁺ ions are present in solution and there are two binding sites for calcium ions in a T2 molecule. The interaction of pradimicin antibiotics with divalent metal ions was thought to be related to ionic electronegativity and to the amphoteric property of the antibiotics.

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